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Studies have demonstrated that hippocampal neurons are highly sensitive to the effects of systemic cytokines, which can alter synaptic plasticity, reduce long-term potentiation (LTP), and impair neurogenesis (Venkateshappa et al., 2012

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Within the context of the Dihexa pathway, which is studied for its ability to support synaptogenesis through HGF/c-Met signaling, having typical BDNF function suggests that the underlying neuroplasticity pathways that support synapse formation and neural network remodeling likely operate within a normal physiological range