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As of July 26, 2026, 21 CFR 216.23 lists six substances that can be used through this pathway: Brilliant Blue G, cantharidin for topical use only, diphenylcyclopropenone for topical use only, N-acetyl-D-glucosamine for topical use only, squaric acid dibutyl ester for topical use only, and thymol iodide for topical use only

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Polycystic ovary syndrome is a common and complex endocrine disorder in women, serving as a significant risk factor for diabetes, cardiovascular diseases, and endometrial cancer, and can lead to irregular menstrual cycles, obesity, infertility, and other issues in women

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