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Genes responsible for the antitumor response are hypermethylated in patients with COPD who smoke, suggesting reduced infiltration of immune cells against tumor [40]

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Meanwhile, we used the upper and lower quintiles to categorise the high and low genetic-risk groups [35, 36], which may reduce the accuracy for the high genetic-risk group but warn a broader population that they need to carry out PRS-informed disease screening or life planning for life-threatening lung cancer