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Studies have shown that low doses of AA can promote ferroptosis and enhance the anti-tumor immune effects induced by immune checkpoint blockade (ICB) therapy (145)
Arch Physiol Biochem 113:234258 Franklin CC, Backos DS, Mohar I, White CC, Forman HJ, Kavanagh TJ (2009) Structure, function, and post-translational regulation of the catalytic and modifier subunits of glutamate cysteine ligase
"The incidence of infusion reactions associated with monoclonal antibody drugs targeting the epidermal growth factor receptor in metastatic colorectal cancer patients: A systematic literature review and meta-analysis of patient and study characteristics"
A hepatic immune response will be triggered by the interaction of PAMPs (e.g., LPS and bacterial RNA) with pathogen recognition receptors such as Toll-like receptor (TLR)4 on hepatic Kuppfer cells, the resident macrophages in the liver sinusoids (130)
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