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Effect of N-acetylcysteine on the spinal-cord glutathione system and nitric-oxide metabolites in rats with neuropathic pain

In the brain, astrocytes play a central role in the GSH metabolism

DA is a G i -biased ligand at 2A -adrenergic receptors We determined whether DA and NE differ in their abilities to initiate intracellular signaling upon activation of D2R and 2A -adrenergic receptors

These differentially expressed proteins were involved in several important biological processes as follows: 95.4% were associated with metabolic process, 47.2% with the oxidation-reduction process, and 30.6% with the electron export (Table 1)