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However, we understood that the experimental condition using in vitro culture of tendon fibroblasts could not mimic the real environment of tendon

Beyond tirzepatide, other incretin-based therapies have shown promise, such as retatrutide, a novel triple-hormone receptor agonist that simultaneously activates GLP-1, GIP, and glucagon receptors, with early-phase trials demonstrating profound effects on weight reduction [36]

However, according to the UKs Medicines and Healthcare products Regulatory Agency (MHRA), the most common side effects of GLP-1 medications are digestive issues, including constipation, diarrhoea, loss of appetite, nausea and vomiting