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The enzyme in the toxin and free radical degeneration process, such as Zinc (Zn), will complement the enzyme to degenerate the toxins just like Alcohol dehydrogenase, which helps to degenerate alcohol

These sequences, named as CIRTs (Cytoplasmic Intron-sequence Retaining Transcripts), comprise only few introns and are limited to small fractions of introns within the gene (Buckley et al., 2013)

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This limitation is expected to be addressed by a dedicated two-phased validation strategy in future work: Phase I Retrospective RNA Validation: This involves prioritizing an intensive search for and inclusion of any suitable independent external RNA-seq cohorts with adequate clinical follow-up data