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Int J Clin Pharmacol Res 10 : 355360 Bidzinska B, Petraglia F, Angioni S, Genazzani AD, Criscuolo M, Ficarra G, Gallinelli A, Trentini GP, Genazzani AR

These results suggested that AMPK pathway was involved in the metformin-induced upregulation of GLP-1R level and PKA phosphorylation in PA-impaired HUVECs

Finally, medication exposure was inferred from prescription records and may not reflect actual adherence

It was initially postulated to be a compensatory mechanism to the blood pressure lowering effect of GLP-1 RAs that was possibly mediated by their vasodilatory effect [9, 31] and/or increased urinary sodium excretion [32]