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based on consistent formation of -helical structure in initial rounds of structure calculations in which no hydrogen bond restraints were defined), inter-molecular PRE restraints (4 non-interacting copies of the spin label to account for different spin label orientations), inter- and intra-molecular NOE restraints, and ambiguous distance restraints for residues showing CSPs upon binding

Source Get the GLP-1 Guide for This Topic Key findings, practical strategies, and evidence-based recommendations backed by the clinical studies cited above

We collaborated with a company in La Jolla, San Diego, and I was there quite a lot also in the 90s

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