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A double-blind, randomized, placebo-controlled trial in 130 PCOS patients showed the combination of letrozole plus 1,200 mg NAC per day resulted in more follicles greater than 18 mm in diameter (a size associated with greater likelihood of ovulation) after five days than letrozole alone or placebo

Bonferroni post hoc test was performed

Pharmacological modulation of cortisol levels, combined with interventions to regulate glutamate clearance and recycling, may help restore neuronal homeostasis and reduce excitotoxicity

Cortisol changes sex hormone-binding globulin levels and can disturb local ovarian and testicular function through inflammatory and metabolic shifts