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Fourman LT, Stanley TL, et al
The FDA also explains that the drugs could cause weight loss, and that "weight loss offers no benefit to a pregnant patient and may cause fetal harm." The FDA recommends that people discontinue the medications at least two months before they plan to become pregnant
[1] Clinical trials also showed that 46% of people using the 0.5mg for a year lost up to 5% of body weight, and 13% of people using it lost up to 10%
Recently, inactivation of the polycomb repressive complex 2 (PRC2), induced by inactivating mutations in two of its critical constituents SUZ12 and EED , was reported in a large subset of malignant peripheral nerve sheath tumors
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