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doi: 10.3389/fonc.2026.1740352 Received 05 November 2025 Revised 28 December 2025 Accepted 13 January 2026 Published 30 January 2026 Volume 16 - 2026 Edited by Felipe DAlmeida Costa, A

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Oral NAD+ absorption can fluctuate significantly depending on the timing of administration, the presence of food in the digestive system, as well as an individuals overall gut health