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Leggas M, Adachi M, Scheffer GL, Sun D, Wielinga P, Du G, Mercer KE, Zhuang Y, Panetta JC, Johnston B, Scheper RJ, Stewart CF, Schuetz JD

It assists in offloading senescent cells, promotes cell survival, and stimulates repair mechanisms among all cells via high-grade autophagy, DNA repair, protections of the epigenome, methylation support, and diminished inflammation and LDL oxidation

Boada M, Lpez OL, Olazarn J, et al

For example, the Y390-containing loop is positioned in a manner similar to our original SCF FBXO22 structure with UNC10088 C and NSD2 versus the BACH1-bound structure, suggesting that the two regions function independently to recruit substrates with minimal interference