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However, whether it is harmful or beneficial for subjects with mild cardiovascular diseases or even those without clinical manifestations is still controversial, likely because of the following reasons: (i) similar strains of mice in different studies from different suppliers differ in baseline bacterial gut microbiome, diet (e.g., different choline levels), age of the mice, animal housing conditions, and duration of the experiment

Open Pharmacol J 2008

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Thus, for every 5.56 C increase in temperature, a 1.3% increase in the incidence of acute appendicitis is reported for temperatures less than or equal to 10.56 C and 2.9% for temperatures greater than 10.56 C [21]