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Drugs (e.g., calcium channel blockers, opiates, antispasmodics, antidepressants) [9] altered autonomic outflow and bowel muscle contraction [10] Endocrine pathology (e.g., hypothyroidism) downregulated bowel motility Neurological pathology (e.g., spinal injury, enteric neuropathy) disease or trauma of bowel innervation Ineffective peristalsis difficult passage of stool regardless of stool consistency sensation of incomplete and irregular bowel emptying References: [10] [11] Approach to management Manage complications Identify and treat fecal impaction

Confirmed HCV genotypes/subtypes

Application of fluorescent probes in reactive oxygen species disease model