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Incubation with GLP-1 and the GLP-1R agonist, exenatide, triggered a cAMP response in MEG-01 cells, with exenatide significantly reducing platelet aggregation induced by thrombin, ADP, and collagen
Oral administration of cysteamine, although efficacious for cystine depletion in nephropathic cystinosis, is associated with poor patient compliance due to the unpalatable taste, odor of sulfur, and gastrointestinal side-effects such as nausea, vomiting and pain, coupled with a requirement for frequent, high dosing to overcome extensive first pass metabolism of the cysteamine
Jamei M, Dickinson GL, Rostami-Hodjegan A
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