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If one averages the effect on A1c of the highest doses for each drug in a specific drug class the reductions in A1c for each class of drug are metformin 1.09%, sulfonylureas 1.0%, TZDs 0.95%, DPP-4 inhibitors 0.66%, SGLT2 inhibitors 0.83%, and GLP-1 RAs 1.24%

The method of action of peptide therapy depends upon the specific peptide utilized, but generally, they work by binding to specific receptors on cells and prompting a response

Always discuss over-the-counter options with your doctor before starting, especially if you take other medications

10.1038/s41598-023-40930-y 95 LiangD.FengY.ZandkarimiF.WangH.ZhangZ.KimJ.et al (2023)