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These occur because the immune system mistakenly identifies the drug as harmful, triggering an allergic response

You should take it extra seriously if you: Take blood thinners (or high-dose aspirin) Use NSAIDs often (ibuprofen, naproxen) Had a peptic ulcer or past GI bleeding Have liver disease (risk of esophageal varices) Drink heavy alcohol often Are older, or you already have anemia Have new belly pain, vomiting, or sudden weakness Even if you feel okay, risk factors raise the chance that black stool is not just food or medicine