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Immunopharmacology 47(23):185201 Levine N, Dorr RT, Ertl GA, Brooks C, Alberts DS (1999) Effects of a potent synthetic melanotropin NI4-D-Phe2 MSH(Melanotan 1) on tanning: a dose range study

doi: 10.1055/s-0042-109065 Summary Keywords diabetes mellitus type 2, cardiovascular disease, cardiovascular risk, diabetic kidney disease, sodium-glucose cotransporter-2 inhibitor, glucagon-like peptide-1 receptor agonist, aldosterone, renin Citation Puglisi S, Rossini A, Poli R, Dughera F, Pia A, Terzolo M and Reimondo G (2021) Effects of SGLT2 Inhibitors and GLP-1 Receptor Agonists on Renin-Angiotensin-Aldosterone System

We assume that by the structure flexibility, shape, and different chemical function properties, thus, assure its reactivity and stability which outline the high affinity to M pro active site leveled by 14 interactions for example conventional hydrogen bond, carbonhydrogen bond, and sulfur bond, these interactions were saved in total acquired conformations, and the favored bonds were saved in both sides of aminopyrimidine and thiazolium ring linked by a methylene bridge with Asn142, Cys145, and Tyr54