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A pivotal consideration is that the weight loss achieved with these medications directly addresses the primary pathophysiological driver of MASLD

Our hope is that doctors exercise restraint and do not prescribe this diabetes medication to people without this serious metabolic disorder

In a Phase 2 obesity trial of retatrutide published in the New England Journal of Medicine in 2023, nausea, diarrhea, vomiting and constipation were cited as the most common adverse events, with higher doses associated with more severe problems

The starting dose is 0.25 mg once a weekyou and your health care professional (HCP) will gradually increase your dose every 4 weeks