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however, further research is warranted to confirm this effect and to investigate the mechanisms through which estrogen interacts with different receptors

What exactly causes vitiligo is difficult to pinpoint, although it is thought to be a combination of a number of factors, including: Autoimmune Reaction: Vitiligo is generally regarded as an autoimmune disease whereby the body begins to attack its own melanocytes (the cells responsible for producing melanin) and either destroys the cells or leaves them damaged and nonfunctional