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Individual factorsage, kidney function, concurrent medications, and body compositionaffect how quickly and effectively dose escalation proceeds

These preclinical observations in rodents promote continued study with the aim of translation to larger animals and specifically primates, the central focus being the quantification of therapeutic index when administered for sustained periods

Without this support, the incredible opportunity they provide can easily be wasted

GLP-1 agonists are more effective than placebo in HbA1c reduction, Z = 5.27, SMD, 0.23, 95% confidence interval (CI), 0.140.32, with 1.2 mg and 1.8 mg more effective than 0.6 mg, SMD, 0.87, 95% CI, 1.60 to 0.13, and SMD, 0.79, 95% CI, 1.18 to 0.41, respectively