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Despite the overwhelming success of GLP-1 medications related to weight loss, GLP-1 therapy is associated with increased cerebral blood flow and reduced small-vessel disease burden, even when controlling for weight loss [15]

In contrast, overexpressing IGF-I in mature osteoblasts increases bone formation, with a significant decrease in the mineralization lag time (the time for osteoid to be mineralized), but without a change in osteoblast number (60)

The most effective approach is targeted: support the specific bacteria and pathways that your gut needs during this transition, rather than throwing general solutions at the problem

Topiramate (Topamax) is not FDA-approved for weight loss