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As rapid elimination is a major challenge for clinical application of GLP-1 RAs, various half-life extension strategies have been successfully employed including sequential modification, attachment of fatty-acid to peptide, fusion with human serum albumin, fusion with the fragment crystallizable (Fc) region of a monoclonal antibody, sustained drug delivery systems, and PEGylation

Chronic postnasal drip from allergies responds to intranasal corticosteroids like fluticasone 50mcg daily, which reduces throat irritation by decreasing mucus production within 2-4 weeks

Studies on animal models confirmed these observations