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A systematic review showed that resveratrol has neuroprotective effect against PD development through different mechanisms including anti-inflammatory, antioxidant, and anti-apoptotic effects with SIRT1 expression and subsequent amelioration of neuroinflammation

Andrographolide inhibits CYP3A4 activity by binding and antagonizing PXR function, and is a potential CYP3A4 inhibitor that may have clinical significance (Ooi et al., 2011)

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Consistent with these studies, a recent study in healthy NS workers demonstrated that moderate alcohol consumption further altered peripheral clock gene amplitude in CLOCK, BMAL1, PER1, CRY1, and CRY2, and it was associated with increased colonic permeability, highlighting the compounding effects of environmental circadian disruption and lifestyle factors on peripheral clock gene regulation 143