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Providers are increasingly seeing side effects such as: Nausea, vomiting, and delayed gastric emptying Fatigue and muscle loss during rapid weight loss Micronutrient depletion from reduced food intake Emotional dysregulation related to appetite and blood sugar swings Plateaus or weight regain after discontinuation Some patients also feel disconnected from their hunger cues or experience anxiety about long-term dependency on injections

Furthermore, exposure of OA FLS to TGF- has been shown to upregulate PRG4 (121)

These studies suggest that FMO3 and TMAO are critical targets for treating hypercholesterolemia (Figure 3)

Corpas FJ, Barroso JB