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As used herein time-extension technology means a peptide time-extension technology for example, recombinant human serum albumin (rHSA), peptide conjugation to a pharmaceutically acceptable polymer, such as polymeric sequence of amino acids (XTEN), unsulfated heparin-like carbohydrate polymer (HEP), hydroxyl ethyl starch (HES), llama heavy-chain antibody fragments (VHH), pegylation, Fc conjugation, bovine serum albumin (BSA) (Sleep, D

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