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Description

The Increlex (mecasermin) FDA label, which covers native rhIGF-1 in pediatric severe primary IGFD, is the closest human reference and informs the contraindications below

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Given that GLP-1 agonists can cause gastroparesis, there is increased concern for ileus when the patient is taking an antipsychotic medication with a high ACB, such as Clozapine, Olanzapine, Quetiapinethe same medications for which we are wanting to manage metabolic side effect consequences

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These changes are generally harmless and often improve as the body adjusts to treatment

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