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Healthcare professionals (HCPs) should look out for any changes in health that may signal progression of T1D, including changes in HbA1c levels or the development of an additional autoantibody

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Chronic mitochondrial ROS production in HF further drives myocyte apoptosis via ROS-mediated activation of caspases and mPTP opening, fibrosis through ROS-activated TGF- signaling in fibroblasts, and electrical instability due to oxidative damage to ion channels, increasing arrhythmia risk

Curr Opin Cardiol 33(4):408415 Stubbusch J, Majdazari A, Schmidt M, Schtz G, Deller T, Rohrer H (2011) Generation of the tamoxifen-inducible DBH-Cre transgenic mouse line DBH-CT