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In another meta-analysis based on 35 trials, which also included trials that had zero outcome events (of thyroid cancer), the risk ratio was 1.30 (95% confidence interval 0.86 to 1.97).45 A nested case-control study that used US databases reported an odds ratio of 1.46 (95% confidence interval 0.98 to 2.19) for thyroid cancer when the GLP1 receptor agonist exenatide was compared with other diabetes drugs.6 More recently, a nested case-control study that used French health insurance data found a hazard ratio of 1.46 (95% confidence interval 1.23 to 1.74) for the association between thyroid cancer and current use of GLP1 receptor agonists compared with non-use of these drugs

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The British National Formulary (BNF) reflects the manufacturers' advice that these medications should not be used during lactation

Summary: There is no direct contraindication between naproxen and Wegovy, but both medications can affect the gastrointestinal system, potentially increasing digestive discomfort or irritation when used together