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In addition, multiple transcription factors, such as ATF3, ATF4, P53, Nrf2, and c-Myc, have been identified as the regulators of SLC7A11 and SLC3A2 transcription [11, 27,28,29,30]
On the pancreatic cancer question specifically, a study of over 540,000 adults found no support for an increased pancreatic cancer incidence over 7 years following start of GLP-1RA treatment. The authors note that longer follow up is still needed, however, and its important to consider how the use of these drugs has skyrocketed recently
If the findings are positive, theyll support the case for using these drugs to reduce health risks associated with weight gain, he added
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