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Vitamin B12 shots can help to prevent the associated complications of deficiency, including heart disease, coordination problems, vision loss, infertility, neurocognitive disorders and peripheral neuropathy

Tyrosine is generally provided in the form of L-tyrosine, which is commercially available for aquafeed supplementation

Interestingly, we transfected 293T cells with Myc-labeled ubiquitin, HA-labeled KEAP1, and Flag-labeled NRF2 plasmids and observed that the upregulation of KEAP1 promoted the poly-ubiquitination of NRF2, and SP could down-regulate the KEAP1 expression and block the NRF2 ubiquitination dose-dependently (Supplementary Fig