Furthermore, L-carnitine upregulates genes involved in fatty acid transport and mitochondrial -oxidation ( Octn2, Cpt1a, Cpt2, Acadm ) while increasing metabolites associated with TCA cycle, urea cycle, and antioxidant pathways (malate, citrulline) (45)
Disorders of metabotropic glutamate (mGlu) receptors and neurotrophins have significant negative effects on neuroplasticity, leading to depression, but LAC regulate brain type 2 metabotropic glutamate (mGlu2) receptors and N-methyl-D-aspartic acid (NMDA) receptors to induce antidepressant effect (8385)
Journal of the Science of Food and Agriculture
In some cases, ashwagandha may: Increase thyroid hormone levels in hypothyroid individuals Decrease thyroid hormone levels in hyperthyroid individuals Help regulate the hypothalamic-pituitary-thyroid (HPT) axis A study on bipolar patients with elevated TSH levels found that ashwagandha supplementation led to a significant reduction in TSH levels