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Dopamine D1 and D2 receptors differentially regulate Rac1 and Cdc42 signaling in the nucleus accumbens to modulate behavioral and structural plasticity after repeated methamphetamine treatment

Investigators in a recent study hypothesized this mechanism as a potential mode of action for TB-500, noting that inhibiting miR-146a appeared to have reversed the suppression of IRAK1 and TRAF6 by T4, indicative of a likely anti-inflammatory mechanism

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