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Although the direction of the association is consistent with randomized trial evidence, the more pronounced mortality reduction observed in our study should be interpreted with caution, as it may partly reflect residual confounding, differences in disease severity or concomitant therapies, and a potential healthy-user effect inherent to observational research

2008 Jun;5(2):191-7

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When to Seek Medical Attention for Back Pain Most back pain associated with weight loss and GLP-1 therapy is mechanical (postural or muscular) and resolves with conservative care