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Prx and GPx require secondary enzymes and cofactors to function efficiently and regulate the cytoplasmic redox system (Chae et al., The overall cellular redox state is determined by two cellular disulfide reductase systems (Das and White, 2002

Although this observation is limited to two cell models, it provides preliminary in vitro evidence supporting a differential cellular response to EGCG-Zn under irradiation

Although generally benign, there has been a rare case reported where a benign macule progressed into malignant melanoma

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