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A 2025 intravenous safety study involving two healthy adults found infusions up to 20 mg well tolerated, with no adverse events or clinically meaningful changes in vital signs or laboratory biomarkers

Theratechnologies / GlobeNewswire (FDA action) (2025) 3

Advantage: Convenient, familiar, non-invasive Challenge: Peptides face proteolytic degradation in the stomach and small intestine Bioavailability: Estimated at approximately 38% based on comparative pharmacology (see below) Transdermal (Patch) Some researchers have explored transdermal patches to deliver peptides: Advantage: Avoids first-pass metabolism and GI degradation Challenge: Intact skin is a strong barrier to peptide penetration Feasibility: Not commonly available commercially