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Gene expression profiling reveals alterations of specific metabolic pathways in schizophrenia

Drives cellular senescence , creating zombie cells that no longer function properly but still release inflammatory chemicals

Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain

Specifically, sulfasalazine, an XCT inhibitor, appears useful in the treatment of pancreatic and small-cell lung cancer cells 69,70 , while NOV-002, a glutathione disulfide mimetic that alters the GSSG/GSH ratio and induces oxidative stress, has been favorably used in patients with HER2-negative breast cancer 71