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The histone deacetylase inhibitor sodium butyrate (NaBu) was found to elevate AKR1C3 transcript and protein levels in GC cell lines (EPG 85-257 and HGC-27), suggesting a potential involvement of decreased AKR1C3 expression in GC development, restorable by NaBu ( While AKR1C3 expression is generally upregulated in various cancer types, it has been found to be downregulated in colon cancer tissues compared to normal tissues

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Dietary fat intake and the risk of incident dementia in the Rotterdam Study