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Second, determining the ideal timing and priority to intensify therapy is also urgently required, since present evidence are not enough to cover this evidence gap

Epilepsy-related BBB disruption also involves activation of mast cells and mechanisms of action of proinflammatory cytokines (142)

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PRP delivers autologous growth factors (PDGF, TGF-beta) directly to injury sites and has FDA approval with established safety profiles, though clinical efficacy remains inconsistent across randomized controlled trials