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In general, the pharmacokinetics, bioavailability and possible side effects of repurposed drugs have been well-characterised, which simplifies the regulatory procedures for drugs and reduces the cost and duration compared to the de novo drug development [1]

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For instance, a colchicine-coordinated nanogel system reduced the dosing frequency and mitigated systemic toxicity in chronic gout models (Yang B

Diabetologia (2013) 56:14136.10.1007/s00125-013-2887-z 38 GrandtDSchimiczekMStrukKShivelyJEysseleinVEGoebellHet alCharacterization of two forms of peptide YY, PYY(1-36) and PYY(3-36), in the rabbit