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It also inhibits the breakdown of cartilage, a flexible tissue that protects the ends of your bones in joints ( A study in 100 people over the age of 50 found that treatment with a supplement containing 1,200 mg of MSM for 12 weeks decreased pain, stiffness and swelling in the joints, compared to a placebo ( The group receiving the supplement also reported improved overall quality of life and less difficulty walking and getting out of bed ( Another study in 32 people with lower back pain found that taking a glucosamine supplement containing MSM significantly reduced lumbar stiffness and pain upon movement, plus greatly increased quality of life ( Summary Studies have shown that MSM is effective in reducing joint pain, stiffness and swelling

The most common side effects are mild and may include slight irritation at the injection site or a temporary metallic taste in the mouth

Scientists initially expected participants with the PAM variant to have lower levels of GLP-1 because the hormone might be less stable without proper amidation

Additionally, L-Carnitine may interact with thyroid hormones