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While prevention is paramount, this growing mechanistic framework raises hypotheses for future studies that targeting mitochondrial metabolism can open windows of epigenetic plasticity toward more positive health outcomes, particularly in subjects with a history of adverse childhood experiences

Natural sources of iron are red meat, poultry, fish, dark leafy greens, lentils, and beans

Several RCTs have investigated whether exercise interventions (up to 96 weeks), involving either aerobic or resistance training alone, or in combination, can improve markers of metabolic health in older adults with T2DM [165-170]

Role of cholesterol efflux and reverse cholesterol transport