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NO is synthesized by eNOS in endothelial cells and diffuses to vascular smooth muscle, where it activates the cytosolic form of guanylate cyclase (also known as guanylyl cyclase) to form cyclic guanosine monophosphate (cGMP)

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Gastrointestinal side effects tend to be worst early on or after a dose increase and frequently ease as your body adjusts over several weeks

This rigorous statistical approach ensures the reliability of the study's conclusions and enhances the overall validity of the results, making them applicable to a broader range of athletic contexts