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sGAGs combine with SOST to restore the signal transduction effect of Wnts

Meister A, Anderson ME (1983) Glutathione Annual Rev Biochem 52(1):711760

Trials 23(1):170

The results from this study indicated that astrocyte-targeting strategy (AST) clearly protected neurons from MPTP neurotoxin in both the young and aged groups, while the effect of AST was less pronounced in older mice, since it could not prevent the decrease in tyrosine hydroxylase (TH) in the nigrostriatal pathway (Grimmig et al., 2018)