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[2] [3] Coenzyme A (CoA) plays a key role in the Krebs cycle in mitochondria, which is essential for the production of ATP, which powers many reactions in cells

Due to accumulation of metabolic intermediates, impaired carnitine biosynthesis, reduced protein intake, and increased removal of carnitine through hemodialysis (HD), patients who undergo routine HD usually present with plasma carnitine insufficiency [54]

L-carnitine increases SOD and CAT expression in H 2 O 2 -damaged HL7702 cells via PPAR- expression Activation of PPAR- by agonists has been previously shown to enhance SOD expression and CAT activity in the liver [19, 20]

doi: 10.1093/rheumatology/kex370 38 KemaIde VriesEMuskietF