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With early clinical data surpassing even the most popular GLP-1 drugs, its shaping up to be a powerful contender in the metabolic treatment landscape

For both therapeutic classes, this increased risk of gallbladder or biliary diseases has been thought to be driven by the inhibition of the secretion of cholecystokinin by GLP-1, leading to impaired gallbladder motility and contractility [64, 65]

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Overall, the cost to treat each 1% reduction of body weight was $985 with tirzepatide and $1845 with semaglutide