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Semaglutide is metabolised in plasma through proteolytic cleavage of the peptide backbone and beta-oxidation of the fatty acid side chain [3]

Semaglutide has been structurally modified to resist DPP-4 degradation and to bind to albumin, resulting in a significantly extended half-life of approximately one week

Researchers who have maintained high protein intake and consistent resistance training throughout the process lose primarily fat, while those who relied on appetite suppression alone show concerning ratios of muscle loss

One study shows that individuals tapering off semaglutide were able to maintain their body weight for 6 months