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doi: 10.3389/fphys.2018.00477 42 LehrerSRheinsteinPH

24 With respect to this, the negative association between frequency of the cSHMT -C1420T variant and latitude documented in this study may indicate that activity of the de novo thymidylate synthesis pathway is increasingly impaired in populations exposed to higher UVR, but the burden of this variant is unclear due to mSHMT likely maintaining cSHMT activity in such cases

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An important feature of these reactions is that they are all reversible, meaning that this phase of the pentose phosphate pathway can operate in either direction