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Researchers used an indirect comparison to evaluate their relative efficacy in patients with T2D inadequately controlled on metformin monotherapy, with change in HbA1c and body weight at approximately one year as the primary outcomes

Studies show that elevated TMAO decreases mTOR and p70S6K expression, causes hippocampal neuron loss and synaptic ultrastructural damage, and worsens cognitive function in mice, with higher TMAO leading to more severe deficits (Li et al., 2018)

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The interaction between ferroptosis and the TME remains poorly defined but is increasingly recognized as a critical area of research